Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics
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چکیده
منابع مشابه
Comparative Effects of Metformin and Glibenclamide on Aortic Reactivity to Vasodilator and Vasoconstrictor Agents in STZ-Induced Diabetic Rats
Background: Diabetes is an important risk factor for cardiovascular events. Endothelial dysfunction is the main reason cause of disability and death in diabetic patients and death. The present study investigates the effects of metformin and glibenclamide on vasoconstrictive and vasodilative responses in the diabetic rat aorta. Methods: Rats were divided into four experimental groups (con...
متن کاملComparison of metformin and chlorpropamide in non-obese, maturity-onset diabetics uncontrolled by diet.
The clinical effectiveness of metformin was compared with that of chlorpropamide in closely similar groups of 216 non-obese patients recently diagnosed as cases of maturity-onset diabetes that could not be controlled by diet. The incidences of primary and secondary drug failures in each group and the numbers of patients satisfactorily maintained on each of the hypoglycaemic agents throughout th...
متن کاملInsulin sensitivity and vascular disease in maturity-onset diabetics.
In 27 maturity-onset diabetics of more than 10 years' duration there was a significant tendency for both atherosclerosis and microangiopathy to be associated with a reduction in the acute hypoglycaemic effect of intravenous beef insulin. This finding is identical to that in a group of 51 insulin-dependent diabetics previously reported.It is suggested that insulin insensitivity probably precedes...
متن کاملComparative Study of the Antioxidant Effects of Metformin, Glibenclamide, and Repaglinide in Alloxan-Induced Diabetic Rats.
Diabetes mellitus is one of the serious global health problems affecting a significant proportion of both developed and developing countries. Overproduction of free radicals and oxidative stress has been associated with the development of diabetic complications. In the present study, the antioxidant effects of metformin (MET), glibenclamide (GLI), and repaglinide (REP) were evaluated in alloxan...
متن کاملon translation of politeness strategies in dialogues involving female characters in translations and retranslations of novels translated before and after the islamic revolution of iran and their effects on the image of women: a polysystem theory approach
abstract reception environment has considerable effects on accepting a translation. as the expectations of a target culture and its values and needs change throughout history, its criteria for accepting a translation or rejecting it will change accordingly (gentzler, 2001). the expectations of iran, as the reception environment in the present study, have changed after the islamic revolution. i...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1977
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00745143